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WHAT IS

Timeless Beauty

Natural-looking results1

With over 30 million treatments worldwide and counting, hyaluronic acid fillers provide natural-looking results by smoothing away facial wrinkles and folds, providing subtle lip enhancement, smoothing the lines around the mouth, and adding lift and volume to the cheeks, and reversing the signs of volume loss in the backs of hands.

LOOK YOUR

Naturally
Expressive Best

Introducing TIMELESS Refyne and TIMELESS Defyne

Our family of fillers help offer just the right amount of lift to laugh lines (nasolabial folds and marionette lines)—all while preserving your ability to show your range of natural facial expressions.1-4

SKIN

Science

HOW TIMELESS WORKS

The Timeless line of products is formulated to act like your body’s own naturally occurring hyaluronic acid, restoring volume to your skin.2,3,5

NASHA© Technology

Our innovative NASHA technology gives each product a unique particle size for tailored treatment.11

FINER PARTICLES
FOR FINE WRINKLES AND
DETAILED SHAPING

MEDIUM-SIZED PARTICLES
FOR MODERATE TO SEVERE
WRINKLES AND FOLDS

LARGER PARTICLES FOR
SEVERE WRINKLES AND
GREATER VOLUME

XpresHAn TechnologyTM

Timeless Refyne and Timeless Defyne are flexible hyaluronic acid gels designed to give you the flexibility to show your natural range of facial expression.1-3,7

For deep smile & laugh lines

OUR

Products

For moderate smile & laugh lines
For facial wrinkles and folds
For lips and the lines around them
For lifted cheeks and smoothed wrinkles

Learn more about more Galderma® aesthetic treatments for frown lines between the eyebrows and collagen stimulation.

FIND A

Specialist

Rewards & Savings

Join Brilliant Distinctions Rewards and treat yourself to an exclusive experience that will help you on your aesthetic journey. Earn points toward treatment certificates by taking bonus quizzes, participating in surveys or referring friends.

It’s easy to join and easy to enjoy — sign up today, and you’ll receive a $20 treatment certificate.

References:

  1. Data on file. 05DF1502 Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2016.
  2. Timeless Refyne. Instructions for Use. Galderma Laboratories, L.P., 2016.
  3. Timeless Defyne. Instructions for Use. Galderma Laboratories, L.P., 2016.
  4. Segura S, Anthoniaz L, Fuchez F, Herbage B. A complete range of hyaluronic acid filler with distinctive physical properties specifically designed for optimal tissue adaptations. J Drug Dermatol. 2012:11(1Suppl):s5-8.
  5. Data on file. Galderma Laboratories, L.P., 2016.
  6. Data on file. RD.06.CIR.18156 Clinical Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2013.
  7. Data on file. MA-32418 Study Report. Fort Worth, TX: Galderma Laboratories, L.P., 2016.
  8. Timeless. Instructions for Use. Galderma Laboratories, L.P., 2016.
  9. Timeless Lyft. Instructions for Use. Galderma Laboratories, L.P., 2018.
  10. Timeless Silk. Instructions for Use. Galderma Laboratories, L.P., 2017.
  11. Cohen JL, Dayan SH, Brandt FS, et al. Systematic review of clinical trials of small- and large-gel-particle hyaluronic acid injectable fillers for aesthetic soft tissue augmentation. Dermatol Surg. 2013;39(2):205-231.

Instructions for Use

Important Safety Information

The Timeless family of products includes Timeless®, Timeless-L®, Timeless® Lyft with Lidocaine, Timeless® Silk, Timeless® Refyne, and Timeless® Defyne.

APPROVED USES
Timeless® and Timeless-L® are for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Timeless® and Timeless-L® are also indicated for injection into the lips in patients over the age of 21.

Timeless® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies in patients over the age of 21. Timeless® Lyft with Lidocaine is also indicated for injection into the subcutaneous plane in the dorsal hand to correct volume deficit in patients over the age of 21.

Timeless® Silk is for lip augmentation and for correction of perioral wrinkles in patients over the age of 21.

Timeless® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.

Timeless® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.

Are there any reasons why I should not use products within the Timeless® family? (Contraindications)

To ensure a safe procedure, your doctor will talk to you about your medical history to determine if you are an appropriate candidate for treatment. You should not use products within the Timeless family if:

  • You have severe allergies with a history of severe reactions (anaphylaxis)
  • You are allergic to lidocaine or to any of the gram-positive bacterial proteins used to make hyaluronic acid
  • You are prone to bleeding or have been diagnosed with a bleeding disorder

Are there other precautions that I should discuss with my doctor?

  • Tell your doctor if you are breastfeeding, pregnant, or trying to become pregnant. The safety of these products for use during pregnancy, or in women who are breastfeeding, has not been studied
  • Timeless, Timeless-L, Timeless® Lyft with Lidocaine, Timeless Refyne and Timeless Defyne are intended to treat facial wrinkles and folds, such as nasolabial folds. Timeless and Timeless-L are also intended for lip enhancement. Timeless® Lyft with Lidocaine is also intended for injection in the dorsal hand to correct volume loss. Treatments in other areas of the face or body have not been evaluated in clinical studies.
  • The safety and effectiveness of Timeless® Silk for areas other than the lips and perioral area have not been evaluated in clinical studies.
  • Tell your doctor if you have any history of scarring, particularly thick and stiff scars, or any pigmentation (skin color) disorders. These side effects can occur with hyaluronic acid fillers in general.
  • Tell your doctor if you are planning other laser treatments or a chemical peel, as there is a possible risk of inflammation at the treatment site if these procedures are performed after treatment
  • Patients who experience skin injury near the site of injection with these products may be at a higher risk for side effects
  • Tell your doctor if you are on any medications to decrease your body’s immune response (immunosuppressive therapy). Using these medications may increase your risk of bruising or bleeding at the gel injection site.
  • Tell your doctor if you are using any “blood thinners” such as aspirin, warfarin, or any other medications that affect bleeding. Using these medications may increase your risk of bruising or bleeding at the gel injection site.
  • The use of these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete. Use of product in these areas could delay healing or make your skin problems worse.
  • Tell your doctor if you have diseases, injuries, or disabilities of the hand.

What are the possible side effects?

The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, itching at the injection site, and impaired hand function. These are typically mild in severity and typically resolve in less than 7 days in nasolabial folds and less than 14 days in lips. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site.

To report a side effect with any of the Timeless products, please call Galderma Laboratories, L.P. at 1-855-425-8722.

As with all skin injection procedures, there is a risk of infection.

One of the risks with using this product is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin.

The Timeless family of products is available only through a licensed practitioner. Complete Instructions for Use are available at www.TimelessUSA.com.

© 2018 Galderma Laboratories, L.P.
All trademarks are the property of their respective owners.